Notes on Cells of Immunology

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B-cells:

• Begin and complete their development in bone barrow.

• Covered by IgM and IgD.

• Each of these antibodies has light chains and heavy chains (joined by hinge region).

• Furthermore, each of these antibodies also contains variable and constant regions.

• These antibodies have a hinge region, connected by disulfide bonds.

• Bind any free floating antigen.

T-cell:

• Begin their development in bone marrow, and complete it in thymus.

• Covered by TCR.

• Two glycoproteins; alpha and beta.

• On the Carboxy terminus of alpha/beta chains contains a membrane for anchoring small antigenic peptides presented by APCs.

• Only bind antigens processed by APCs.

Receptor Diversity:

• B-cell variable heavy region: V, D, L; Tdt randomly inserts bases at their junctions.

• B-cell variable light region: V, J; Tdt not active here.

• T-cell variable heavy (?) region: V, D, L; beta chain; Tdt randomly inserts bases at their junctions.

• T-cell variable light (?) region: V, J; alpha chain; Tdt randomly inserts bases at their junctions.

Tdt Cell Marker:

• T/B cell ALL marker.

Additional Readings:

Basic Immunology

1. Introduction to Immunology
2. Cells of Immunology
3. Selection of Lymphocytes
4. Primary Response to Antigen
5. Antigen Processing and Presentation
6. Humoral Effector Mechanism Generator
7. Cell-Mediated Effector Mechanism Generator
8. Vaccination and Immunotherapy
9. Immunodeficiency Diseases
10. Acquired Immunodeficiency Syndrome
11. Hypersensitivities and Autoimmunity Diseases
12. Immunology of Transplantation
13. Immunology of Cancer
14. Immunology Laboratory Technology
15. Acquired Immunity
16. Type II Hypersensitivity Reaction
17. Hypersensitivity Reactions
18. Primary Immunodeficiency
19. Secondary Immunodeficiency
20. Type III Hypersensitivity Reaction
21. Type IV Hypersensitivity Reaction
22. Type V Hypersensitivity Reaction
23. Tumor Immunology
24. Images of Antibodies
25. Th1 vs Th2 cells

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1. Histology of Lymphoid Tissue

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