Effects of Drugs on Fetal Development

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Drugs: Effects:
Phenobarbital Vitamin K deficiency.
Alcohol Fetal alcohol syndrome.
Isotretinoin Facial/ear abnormalities; congenital heart disease.
Phenytoinyl Hypoplastic nails, typical facies, IUGR.
Diethylstilbestrol (DES) Vaginal adenocarcinoma.
Tetracycline Enamel hypoplasia, discolored teeth.
Lithium Ebstein anomaly.
Warfarin Facial dysmorphism and chondrodysplasia.
Valproate/Carbamazepine Mental retardation, neural tube defects.
ACE inhibitors Craniofacial abnormalties.

Additional Readings:

Basic Embryology

1. Early Development and Disorders
2. Differentiation and Anatomy of a Blastocyst
3. Differentiation of the Face
4. Effects of Drugs on Fetal Development

Related Topics

1. Genetic and Developmental Disorders
2. Notes on Fetal Circulation
3. Prenatal Infections

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